{"id":14748,"date":"2020-09-18T12:16:10","date_gmt":"2020-09-17T23:16:10","guid":{"rendered":"https:\/\/clladvocates.nz\/?p=14748"},"modified":"2020-09-18T12:16:10","modified_gmt":"2020-09-17T23:16:10","slug":"uncommon-mutation-in-cll-associated-with-more-favorable-prognostic-factors","status":"publish","type":"post","link":"https:\/\/clladvocates.nz\/?p=14748","title":{"rendered":"Uncommon Mutation in CLL Associated With More Favorable Prognostic Factors"},"content":{"rendered":"

[vc_row row_height_percent=”0″ override_padding=”yes” h_padding=”2″ top_padding=”3″ bottom_padding=”3″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column column_width_percent=”100″ gutter_size=”3″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_custom_heading heading_semantic=”h1″ text_size=”h1″]<\/p>\n

Uncommon Mutation in CLL Associated With More Favorable Prognostic Factors<\/h1>\n

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[\/vc_custom_heading][vc_column_text]This article was originally published by Cancer Therapy Advisor\u00a0<\/a><\/p>\n

Patients with chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had an\u00a0MYD88<\/em>\u00a0L265P mutation were uncommon and had distinct features, reported a cohort study in\u00a0Blood Cancer Journal<\/em>.<\/p>\n

Study researchers identified 56 (3.1%) patients with CLL\/SLL who had\u00a0MYD88<\/em>\u00a0mutations among 1779 who underwent mutational analysis. The study also included 100 patients who did not have\u00a0MYD88<\/em>\u00a0mutations to serve as a control group.<\/p>\n

Among patients with\u00a0MYD88<\/em>\u00a0mutations, 38 (68%) had the L265P mutation and 18 (32%) had non-L265P mutations, which included 10 with V217F and 4 with M232T. Among the remaining patients with non-L265P mutations, 2 had a single-nucleotide mutation, 1 with S219C and the other with A6fs, and 2 had concurrent mutations, 1 with N291S\/T294P and the other with F252I\/M232T.<\/p>\n

No morphological differences were seen, as all patients had a typical CLL morphology. In general, patients with non-L265P mutations had similar features to patients with wild-type\u00a0MYD88<\/em>.<\/p>\n

To continue reading this article on Cancer Therapy Advisor<\/a>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Patients with CLL\/small lymphocytic lymphoma (CLL\/SLL) who had an MYD88 L265P mutation were uncommon and had distinct features, <\/p>\n","protected":false},"author":1,"featured_media":14749,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[17,23],"tags":[],"class_list":["post-14748","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","category-research"],"jetpack_featured_media_url":"https:\/\/clladvocates.nz\/wp-content\/uploads\/2020\/09\/Capture-cll.1.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/14748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14748"}],"version-history":[{"count":1,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/14748\/revisions"}],"predecessor-version":[{"id":14750,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/14748\/revisions\/14750"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/media\/14749"}],"wp:attachment":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=14748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=14748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}