{"id":2000,"date":"2020-07-07T16:54:26","date_gmt":"2020-07-07T03:54:26","guid":{"rendered":"https:\/\/clladvocates.nz\/?p=2000"},"modified":"2020-07-07T16:54:26","modified_gmt":"2020-07-07T03:54:26","slug":"changes-in-management-of-cll-due-to-covid-19-noted-in-italy","status":"publish","type":"post","link":"https:\/\/clladvocates.nz\/?p=2000","title":{"rendered":"Changes in Management of CLL Due to COVID-19 Noted in Italy"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;h1&#8243; text_size=&#8221;h1&#8243;]<\/p>\n<h1 class=\"post-heading heading\">Changes in Management of CLL Due to COVID-19 Noted in Italy<\/h1>\n<p>[\/vc_custom_heading][vc_column_text]<a href=\"https:\/\/www.cancertherapyadvisor.com\/home\/cancer-topics\/chronic-lymphocytic-leukemia\/covid19-coronavirus-chronic-leukemia-cll-changes-management-italy\/\">This article was originally published by Cancer Therapy Advisor.<\/a><\/p>\n<p>The clinical management of patients with chronic lymphocytic leukemia (CLL) was altered across Italy in response to the COVID-19 pandemic, according to a survey study published in\u00a0<em>Blood<\/em>.<\/p>\n<p>\u201cWhat is starting to emerge is an impact on the routine work-up of patients, on treatment choices, and the enrollment and adherence to clinical trials,\u201d the authors wrote.<\/p>\n<p>The authors sent a survey to 33 hematology centers across Italy in early April that included questions about testing strategies for COVID-19; the effect of the pandemic on diagnosis, management, and the outcomes of patients with CLL; and the adherence to clinical protocols. The survey data was based on 9930 patients with CLL, which represents approximately one-third of all patients with CLL in Italy.<\/p>\n<p>Although the minimum testing requirements mandated by law were followed by all centers, only 30% of centers tested asymptomatic patients without any known contact with a COVID-19 case prior to initiating CLL treatment. The authors said that this \u201creflects the higher capacity of some regional health systems to performed analyze nasopharyngeal swabs.\u201d<\/p>\n<div class=\"reco-in-article\">\n<div class=\"reco-in-article-title\">Today\u2019s Top Picks for You on Cancer Therapy Advisor<\/div>\n<div id=\"bibblio_recommended_box\">\n<div class=\"bib__module bib--row-3 bib--txt-3\"><a class=\"bib__link bib__link--1 bib__link--image\" href=\"https:\/\/www.cancertherapyadvisor.com\/home\/cancer-topics\/chronic-lymphocytic-leukemia\/chronic-leukemia-cll-patients-coronavirus-covid19-longer-incubation\/\" target=\"_self\" data-feathr-click-track=\"true\" rel=\"noopener noreferrer\"><span class=\"bib__info\"><span class=\"bib__title\"><span class=\"bib__name\">Patient With CLL May Have Had Longer COVID-19 Incubation Period<\/span><\/span><\/span><\/a><a class=\"bib__link bib__link--2 bib__link--image\" href=\"https:\/\/www.cancertherapyadvisor.com\/uncategorized\/covid19-dietary-supplements-vitamins-lack-evidence-zinc-elderberry-vitamin-c\/\" target=\"_self\" data-feathr-click-track=\"true\" rel=\"noopener noreferrer\"><span class=\"bib__info\"><span class=\"bib__title\"><span class=\"bib__name\">Evidence Supporting Dietary Supplement Use for COVID-19 Lacking<\/span><\/span><\/span><\/a><a class=\"bib__link bib__link--3 bib__link--image\" href=\"https:\/\/www.cancertherapyadvisor.com\/home\/cancer-topics\/hematologic-cancers\/risk-for-thrombotic-disorders-up-in-patients-with-covid-19\/\" target=\"_self\" data-feathr-click-track=\"true\" rel=\"noopener noreferrer\"><span class=\"bib__info\"><span class=\"bib__title\"><span class=\"bib__name\">Clotting and COVID: New Guidelines in the Works to Treat Coagulopathies in Patients With COVID-19<\/span><\/span><\/span><\/a><\/div>\n<\/div>\n<\/div>\n<div class=\"reco-in-article-h-line\">\n<hr \/>\n<p>CONTINUE READING<\/p>\n<\/div>\n<div><\/div>\n<p>Of the 9330 patients with CLL, 47 (0.5%) patients were symptomatic and tested positive for COVID-19.<\/p>\n<p>Most centers reported a decrease in the number of newly diagnosed CLL cases, likely due to a decrease in the use of peripheral laboratories for diagnostic work-up, the authors said. In addition, 15.2% of centers reported that delays and difficulties in an accurate diagnostic work-up has occurred due to a reduction in personnel.<\/p>\n<p>New treatment initiation was delayed in 79% of centers, and 24% of centers reported a delay in ongoing therapy. Delayed post-treatment restaging also occurred in 30.3% of centers.<\/p>\n<p>The sample size was not large enough to characterize patient outcomes due to COVID-19 or the effect of\u00a0<a href=\"https:\/\/www.cancertherapyadvisor.com\/home\/cancer-topics\/chronic-lymphocytic-leukemia\/\" data-feathr-click-track=\"true\">anti-CLL<\/a>\u00a0treatments. However, there was a mix of patients who were receiving active first-line or salvage treatment vs no active treatment.<\/p>\n<p>The mortality rate in this cohort was 30.4%. \u201cThe mortality rate for symptomatic COVID-19 patients amongst the general population was 13.4% and 25.5% in the 70- to 79-year-old population,\u201d the authors noted.<\/p>\n<p>Clinical trial enrollment and follow-up of patients on a clinical trial protocol was reduced in two-thirds of the centers.<\/p>\n<p>The authors concluded that this survey has revealed that COVID-19 \u201chas started to impact on the number of new cases, on the adequate follow-up of treated patients, on the number of patients enrolled in clinical trials, and on the monitoring of such patients.\u201d[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The management of CLL, including delays in work-up and treatment, and modifications to clinical trials, have been implemented across Italy in response to the COVID-19 pandemic.<\/p>\n","protected":false},"author":1,"featured_media":2001,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[17,22],"tags":[],"class_list":["post-2000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","category-covid19"],"jetpack_featured_media_url":"https:\/\/clladvocates.nz\/wp-content\/uploads\/2020\/07\/COVID-19.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/2000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2000"}],"version-history":[{"count":1,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/2000\/revisions"}],"predecessor-version":[{"id":2002,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/2000\/revisions\/2002"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/media\/2001"}],"wp:attachment":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}