{"id":619,"date":"2019-08-28T22:57:27","date_gmt":"2019-08-28T22:57:27","guid":{"rendered":"https:\/\/clladvocates.nz\/?p=619"},"modified":"2019-09-12T01:36:38","modified_gmt":"2019-09-12T01:36:38","slug":"new-study-reports-curative-potential-of-a-combination-therapy-for-some-leukemia-patients","status":"publish","type":"post","link":"https:\/\/clladvocates.nz\/?p=619","title":{"rendered":"New Study Reports \u201cCurative Potential\u201d of a Combination Therapy for Some Leukemia Patients"},"content":{"rendered":"

[vc_row row_height_percent=”0″ override_padding=”yes” h_padding=”2″ top_padding=”3″ bottom_padding=”3″ overlay_alpha=”50″ gutter_size=”3″ column_width_percent=”100″ shift_y=”0″ z_index=”0″][vc_column width=”1\/1″][vc_custom_heading heading_semantic=”h1″ text_size=”h1″]<\/p>\n

New Study Reports \u201cCurative Potential\u201d of a Combination Therapy for Some Leukemia Patients<\/p>\n

[\/vc_custom_heading][vc_column_text]This article was originally published on Dana-Farber Cancer Institute<\/a><\/p>\n

Chemoimmunotherapy combined with a targeted drug given for two years has achieved undetectable minimal residual disease (MRD) for a high proportion of younger patients with\u00a0chronic lymphocytic leukemia (CLL)<\/a>, Dana-Farber scientists report.<\/p>\n

The phase 2 clinical trial results are so favorable that they represent a step toward \u201ca new standard of care with curative potential for a broad population of younger, fit patients\u201d with CLL, say the investigators, led by\u00a0Matthew Davids, MD, MMSc<\/strong><\/a>, and\u00a0Jennifer Brown, MD, PhD<\/a><\/strong>. \u201cYounger\u201d in this setting is 65 years of age or below.<\/p>\n

The\u00a0report<\/a>\u00a0in\u00a0The Lancet Haematology\u00a0<\/em>describes the regimen administered to 85 patients with CLL whose median age was 55 years. The study looked at individuals whose cancer carried a mutated\u00a0IGHV\u00a0<\/em>gene \u2014 which confers a higher likelihood of a long-lasting response to chemotherapy \u2014 and those with an unmutated\u00a0IGHV\u00a0<\/em>gene \u2014 who rarely have durable responsesto chemotherapy.<\/p>\n

The study examined the combined effect of two different treatment options for CLL patients. The first, chemoimmunotherapy consisting of fludarabine, cyclophosphamide, and rituximab (FCR), can improve overall survival for younger fit patients with CLL who have an\u00a0IGHV\u00a0<\/em>mutation. The second, the targeted drug ibrutinib, can be effective for CLL patients irrespective of their\u00a0IGHV<\/em>status, but requires continuous treatment. The clinical trial examined if FCR plus time-limited ibrutinib could achieve long-lasting responses in younger, fit patients with either mutational status.<\/p>\n

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The patients, who were previously untreated, received oral ibrutinib for seven days, then up to six 28-day cycles of FCR along with continuous ibrutinib. Responders continued on maintenance ibrutinib for up to two years, and those who had undetectable MRD in bone marrow after two years were able to stop treatment.<\/p>\n

Thirty-three percent of patients achieved the primary endpoint \u2014 a complete response with undetectable minimal residual disease in bone marrow two months after the last cycle of ibrutinib plus FCR. A best response of undetectable minimal residual disease in bone marrow was achieved by 84 percent of patients at any time during the study. \u201cMany of the patients had deepening responses while on the two years of ibrutinib maintenance, so later converted to undetectable MRD,\u201d explains Davids.<\/p>\n

The researchers say the results of the trial demonstrated that the combination of chemotherapy and two years of ibrutinib maintenance leads \u201cto the best of our knowledge, to the highest proportion of patients achieving undetectable minimal residual disease in the bone marrow ever published for any regimen used to treat this disease.\u201d The approach, they add, could increase the potential to \u201cfunctionally cure patients with mutated\u00a0IGHV\u00a0<\/em>and, importantly, might for the first time extend this potential to patients with unmutated\u00a0IGHV.\u201d<\/em>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Chemoimmunotherapy combined with a targeted drug given for two years has achieved undetectable minimal residual disease (MRD) for a high proportion of younger patients with chronic lymphocytic leukemia (CLL), Dana-Farber scientists report.<\/p>\n","protected":false},"author":1,"featured_media":661,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-619","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-media"],"jetpack_featured_media_url":"https:\/\/clladvocates.nz\/wp-content\/uploads\/2019\/08\/SOG_5276_16_adj-536x402.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=619"}],"version-history":[{"count":2,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/619\/revisions"}],"predecessor-version":[{"id":662,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/posts\/619\/revisions\/662"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=\/wp\/v2\/media\/661"}],"wp:attachment":[{"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/clladvocates.nz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}