Genetic Prognostic Factors in CLL Treated With Novel Compounds
This article was originally published by Cancer Therapy Advisor
Treatment with obinutuzumab plus venetoclax (VenG) was associated with improved outcomes compared with obinutuzumab plus chlorambucil (CGlb) among patients with chronic lymphocytic leukemia (CLL) and established unfavorable genetic factors, according to a study published in Blood.1
“Genetic parameters are established prognostic factors in chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy, but are less well studied with novel compounds,” the authors wrote.
Unmutated IGHV, mutated TP53, and deletion of chromosome 17p (del[17p]) that contains the TP53 locus, are associated with progression and shorter survival among patients with CLL treated with chemoimmunotherapy. Other genetic markers have been identified that are also prognostic for outcomes.
This analysis used data from the multicenter, phase 3 CLL14 trial, which randomly assigned 432 patients with CLL to receive first-line VenG or CGlb. The analysis used fluorescence in situ hybridization (FISH), DNA sequencing, and next-generation sequencing to evaluate genetic prognostic factors.